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Based on a best selling novel of the same name, Confusion of Genders is an uninhibited romantic satire that tells the story of Alain (Pascal Greggory), who is having an office romance with a female colleague Laurence (Nathalie Richard). Unfortunately her younger brother Christophe (Cyrille Thouvenin) likes him as well. Alain however, doesn't know what he wants. Men, women, commitment and freedom are luring him in every direction but he is incapable of choosing. Or willing. When Alain encounters sexy, dangerous Marc (Vincent Martinez), the only way to get close to him is to become the messenger of Marc's passion (the sexy Babette, played by Julie Gayet), an entrancing woman whose charms Alain can not resist. Unfortunately, by this time, Christophe has moved into Alain's flat and Laurence is expecting his child and his hand in marriage. Will Alain find a compromise that will be acceptable to all?