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The Rescue Aid Society, an international organization of mice with headquarters in the basement of the United Nations building, receives a plea for help from a little orphan girl named Penny who has been kidnapped by an evil woman, Madame Medusa. Medusa intends to use her to retrieve a fabulous diamond, the Devil's Eye, from a pirate cave. The case is taken by lovely Bianca and Rescue Aid Society custodian Bernard, who becomes her shy assistant. Together, after avoiding two brutish alligators, enlisting the help of the local swamp folk, and turning Medusa and her henchman Snoops against themselves, they rescue Penny and the diamond.